Top 5 Gout Treatments Gout Can Affect Your Entire Life, We Can Help ... Gout Overview Gout Top 5 Rating

Krystexxa® (pegloticase) Review

Editor's Rating:

Krystexxa is a PEGylated uric acid specific enzyme that is sometimes used in the treatment of chronic gout in adults who are not responding to other conventional treatments.

Patients who fail to respond to xanthine oxidase blockers or in whom serum uric acid level is not normalized with conventional therapy may be given Krystexxa. Genetically modified E.coli produces the enzyme. Krystexxa catalyzes the oxidation of uric acid to allantoin, which is water soluble and is easily removed through urine.

Active Ingredient

• 8mg/ml pegloticase in a phosphate-buffered saline

Recommended Dosage

Usually doctors prescribe one dose (8mg) of Krystexxa every 2 weeks or 4 weeks depending on uric acid levels in blood. This needs to be given as an intravenous infusion over no less than 120 minutes via gravity feed, syringe type pump or infusion pump. A healthcare provider should administer this drug in a health care setting, so that they can be prepared to deal with anaphylaxis or infusion reactions, if they occur. They will also need to monitor the patient after administering the dose and keep a close check on serum uric acid levels.

Possible Side Effects

There are many serious side effects associated with this treatment. These include gout flares (in about 77% cases), infusion reactions (patients should be pre-medicated with antihistamines and corticosteroids before giving Krystexxa), anaphylaxis in 5% of the patients and heart failure in patients with a pre-existing heart condition. Less serious side effects include nausea, contusion, nasopharyngitis, constipation, chest pain, and vomiting. It is also contraindicated for use in patients with a Glucose-6-phosphate dehydrogenase Deficiency. It should not be used in individuals below 18 years of age.


The price per dose is a whopping $5,390.


The FDA has recently approved this treatment for gout and gouty arthritis.

Krystexxa Overall Value

This drug should be taken only when prescribed by a physician and only in a hospital setting. It is an extremely expensive treatment and has many serious side effects. It is however, covered under some insurance policies as long as certain conditions are met.

Click here to learn about our Top Gout Products.

Top 5 Gout Products for 2020


Gout Center Top 5 Rating


GoutClear Goutezol Flamasil GR-911 Uricinex
1 2 3 4 5
Price (1 bottle)
Price (6 bottles) Best Value
Overall Rating 99.10% 78% 73.50% 62.40% 62%
Speed of Results* Extremely Fast Fast Average Slow Slow
Quality of Ingredients Premium Good Good Average Unknown
Customer Satisfaction Evaluation 99.10% 80% 75.20% 73% 61.10%
Safety Evaluation Safe for Use Safe for Use Safe for Use Safe for Use Safe for Use
Customer Service Rating
Reorder Rate Highest Good Average Average Average
Return Policy Risk Free Unused Unopened + Restocking Fee Unopened 2 opened only
Success Rate 97.30% 77.30% 73% 75.10% 62%

*The views and opinions expressed in this page are strictly those of the Editor. Results may vary from person to person and cannot be guaranteed.

Our Top 5 Picks

Editor's Choice
Top 5 Picks
Click Here